OUR RESEARCH AND PUBLICATIONS
Published Manuscripts
Hari Ram Pampana , Sadguri Addanki , Dhanunjaya Varma Lakkamraju , John Dogulas Palleti , Sudhakar Godi , Paddaiah Gangisetti. Assessing the Impact of Cultural, Socio-Economic, and Health Disparities on Chronic Kidney Disease: A Case-Control Study in Uddanam, Andhra Pradesh. African Journal of Biological Sciences, Volume 6, Issue-13(2024).doi:10.48047/AFJBS.6.13.2024.6910-6926
Nigusu Birhanu, Krishna Chaithanya K, Zenebe Hagos, John Dogulas Palleti, Samoju Rushmitha, Godavarthi Rajan Bhagyasri, Kamalakararao K, Naveen Kumar A.D, Exploring the Anti-Inflammatory Potential: Phytochemical Screening and In Vitro Dual Inhibition of 5-LOX and COX by Vernonia amygdalina Leaf Extract, African Journal of Biological Sciences, 6(Si4)(2024).doi: 10.48047/AFJBS.6.Si4.2024.523-536.
Sudha Rani B, John Dogulas P, Kiranmayi P. Elucidating the Impact of High-Altitude Vanajangi Soils on Protein Profiles of Exotic Edible Mushrooms: A Proteomic Analysis. Advances in Bioresearch. Vol 15 [1] January 2024. 01-07. DOI: 10.15515/abr.0976-4585.15.1.0107.
Tesfay Weletnsae, Tekleweyni Tadege, Kidu Hintsa, Zenebe Hagos, Davuluri Syam Babu, John Dogulas Palleti, Godavarthi Rajan Bhagyasri, Sudhish Rai, Krishna Chaithanya K. In vitro Screening of 5-LOX /COX-2 Dual Inhibitors from selected Medicinal plant Maytenus arbutifolia. Research Journal of Pharmacy and Technology. 2024; 17(1):241-8. doi: 10.52711/0974-360X.2024.00038
Dhanunjaya Varma Lakkamraju, Sadguri Addanki, Hari Ram Pampana, John Dogulas Palleti, Sudhakar Godi and Paddaiah Gangisetti. Understanding the impact of Chronic Kidney Disease: A study of demographic, anthropometric and plasma Protein polymorphism in uddanam region, Andhra Pradesh, India. World journal of pharmacy and pharmaceutical sciences. 2023, Volume 12, Issue 7, 1998-2012. https://storage.googleapis.com/journal-uploads/wjpps/article_issue/1688541500.pdf
Trhas Tesfay, Berihu Tekluu, Krishna Chaithanya K, Dhanunjaya Varma Lakkamraju, John Dogulas Palleti, Sudhish Rai, Kamalakararao K. In vitro Anticancer activity of Rumex abyssinicus root extracts on breast cancer MCF-7 cell lines. Research Journal of Pharmacy and Technology. 2023; 16(11):5410-5. doi: 10.52711/0974-360X.2023.00876
Berihu Tekluu, Krishna Chaithanya K, Tesfay Welderfael, Tekleweyni Tadege, Hailu Weldekiros Hailu, Yemane Hailu, Brahmam Pasumarthi, John Dogulas Palleti. Phytochemical Analysis and Evaluation of in vitro Antioxidant potential of Ethanolic Stem Bark Extract of Balanites aegyptiaca Del. Research Journal of Pharmacy and Technology, 2023; 16(9):4302-6. doi: 10.52711/0974-360X.2023.00704
Haftamu Tesfay Berihu, Tesfay Welderfael, Berihu Tekluu, V. K. Gopalakrishnan, M. Rama Rao, P. P. N. Vijay Kumar, U. Shameem, P. John Dogulas & K. Krishna Chaithanya. Anti-inflammatory and Cytotoxicity activities of Green Synthesized Silver Nanoparticles from Stem Bark of Terminalia brownii. BioNanoSci. 2021. https://doi.org/10.1007/s12668-021-00885-8
Ongoing Projects
1. Machine Learning in
Bioinformatics:
- Research Focus: Developing and applying
machine learning models for genomic data analysis, such as variant
calling, gene expression profiling, and evolutionary analysis.
- Potential Topics: Predictive modeling for
disease susceptibility, disease classification based on gene expression,
and machine learning models for biomarker discovery.
2. Phytochemical Screening and
Drug Discovery:
- Research Focus: Investigating bioactive
compounds from medicinal plants for their therapeutic potential.
- Potential Topics: Screening and characterizing
phytochemicals with antibacterial, antifungal, or antioxidant properties;
using molecular docking to predict interactions between phytochemicals and
disease-related proteins.
3. Environmental
Bioinformatics and Ecosystem Health:
- Research Focus: Applying bioinformatics to
understand environmental health, pollution effects, and ecosystem
resilience.
- Potential Topics: Genomic analysis of
microbes involved in bioremediation, the impact of pollution on microbial
diversity, and predictive modeling for environmental health.
4. Genomic Data Analysis for
Personalized Medicine:
- Research Focus: Using genomics to understand
individual variation in disease risk and drug response.
- Potential Topics: Comparative genomics to
identify personalized treatments for chronic diseases, genome-wide
association studies for disease susceptibility, and pharmacogenomic
approaches for tailored therapies.
5. Antimicrobial Resistance
(AMR) Prediction and Mitigation:
- Research Focus: Investigating antimicrobial
resistance using computational and molecular approaches to help tackle AMR
in pathogens.
- Potential Topics: Prediction of resistance
genes in bacterial genomes, computational models for AMR pathway analysis,
and development of alternative antimicrobial compounds from natural
sources.
6. Computational Modeling of
Protein-Protein Interactions:
- Research Focus: Studying protein
interactions to understand cellular processes and identify drug targets.
- Potential Topics: Structural modeling of
protein complexes involved in diseases, computational docking studies to
screen inhibitors, and machine learning to predict protein interaction
networks.
7. Epigenetics and Disease
Mechanisms:
- Research Focus: Understanding how epigenetic
modifications influence disease onset and progression.
- Potential Topics: The role of DNA
methylation in chronic kidney disease, histone modification patterns in
cancer, and the impact of environmental factors on epigenetics in
autoimmune disorders.
8. Computational Analysis of
Non-Coding RNA:
- Research Focus: Analyzing the roles of
non-coding RNAs (e.g., miRNAs, lncRNAs) in gene regulation and disease.
- Potential Topics: Functional
characterization of miRNAs in kidney disease, bioinformatics approaches
for non-coding RNA annotation, and network analysis of lncRNA interactions
in cancer.
9. Air Quality Assessment and
Health Impacts:
- Research Focus: Assessing air pollution
levels and their effects on public health, using computational models and
data analysis.
- Potential Topics: Monitoring air pollutants
at highway junctions, assessing health risks from vehicle emissions, and
developing predictive models for air quality and respiratory health.
10. Bioinformatics in
Agriculture:
- Research Focus: Applying bioinformatics
tools to improve crop health, resilience, and productivity.
- Potential Topics: Genomic analysis of crop
plants for disease resistance, microbial diversity in soil health, and
identifying gene markers for yield optimization.
11. Integrative Approaches in
Chronic Kidney Disease (CKD):
- Research Focus: Investigating the genetic,
epigenetic, and environmental factors contributing to CKD.
- Potential Topics: Genetic analysis of CKD
risk variants, studying the role of mitochondrial DNA in kidney function,
and identifying biomarkers for early detection.
12. Microbiome and Human
Health:
- Research Focus: Studying the human
microbiome and its role in health and disease.
- Potential Topics: Gut microbiome analysis in
metabolic diseases, microbial dysbiosis and immune response, and the
impact of dietary factors on microbiome composition.
13. Development of
Bioinformatics Tools and Software:
- Research Focus: Creating new computational
tools and algorithms for analyzing biological data.
- Potential Topics: Developing software for
data visualization, pipeline automation for genomic analysis, and
web-based platforms for multi-omics integration.
14. Bioinformatics in Mental
Health and Neuroscience:
- Research Focus: Exploring bioinformatics
applications in understanding brain disorders.
- Potential Topics: Identifying genetic risk
factors for neurological diseases, machine learning models for psychiatric
disorder prediction, and network analysis of brain gene expression.
15. Green Chemistry and
Sustainable Biotechnology:
- Research Focus: Applying bioinformatics and
computational methods to green chemistry and biotechnology for sustainable
solutions.
- Potential Topics: Screening plant-based
compounds for eco-friendly alternatives, computational approaches to
enzyme optimization for biofuel production, and assessing environmental
impacts of bioproducts.