OUR RESEARCH AND PUBLICATIONS

Published Manuscripts

 Hari Ram Pampana , Sadguri Addanki , Dhanunjaya Varma Lakkamraju , John Dogulas Palleti , Sudhakar Godi , Paddaiah Gangisetti. Assessing the Impact of Cultural, Socio-Economic, and Health Disparities on Chronic Kidney Disease: A Case-Control Study in Uddanam, Andhra Pradesh. African Journal of Biological Sciences, Volume 6, Issue-13(2024).doi:10.48047/AFJBS.6.13.2024.6910-6926

Nigusu Birhanu, Krishna Chaithanya K, Zenebe Hagos, John Dogulas PalletiSamoju Rushmitha, Godavarthi Rajan Bhagyasri, Kamalakararao K, Naveen Kumar A.D, Exploring the Anti-Inflammatory Potential: Phytochemical Screening and In Vitro Dual Inhibition of 5-LOX and COX by Vernonia amygdalina Leaf Extract, African Journal of Biological Sciences, 6(Si4)(2024).doi: 10.48047/AFJBS.6.Si4.2024.523-536.

Sudha Rani B, John Dogulas P, Kiranmayi P. Elucidating the Impact of High-Altitude Vanajangi Soils on Protein Profiles of Exotic Edible Mushrooms: A Proteomic Analysis. Advances in Bioresearch. Vol 15 [1] January 2024. 01-07. DOI: 10.15515/abr.0976-4585.15.1.0107.

Tesfay Weletnsae, Tekleweyni Tadege, Kidu Hintsa, Zenebe Hagos, Davuluri Syam Babu, John Dogulas Palleti, Godavarthi Rajan Bhagyasri, Sudhish Rai, Krishna Chaithanya K. In vitro Screening of 5-LOX /COX-2 Dual Inhibitors from selected Medicinal plant Maytenus arbutifolia. Research Journal of Pharmacy and Technology. 2024; 17(1):241-8. doi: 10.52711/0974-360X.2024.00038

Dhanunjaya Varma Lakkamraju, Sadguri Addanki, Hari Ram Pampana, John Dogulas Palleti, Sudhakar Godi and Paddaiah Gangisetti. Understanding the impact of Chronic Kidney Disease: A study of demographic, anthropometric and plasma Protein polymorphism in uddanam region, Andhra Pradesh, India. World journal of pharmacy and pharmaceutical sciences. 2023, Volume 12, Issue 7, 1998-2012. https://storage.googleapis.com/journal-uploads/wjpps/article_issue/1688541500.pdf

Trhas Tesfay, Berihu Tekluu, Krishna Chaithanya K, Dhanunjaya Varma Lakkamraju, John Dogulas Palleti, Sudhish Rai, Kamalakararao K. In vitro Anticancer activity of Rumex abyssinicus root extracts on breast cancer MCF-7 cell lines. Research Journal of Pharmacy and Technology. 2023; 16(11):5410-5. doi: 10.52711/0974-360X.2023.00876 

Berihu Tekluu, Krishna Chaithanya K, Tesfay Welderfael, Tekleweyni Tadege, Hailu Weldekiros Hailu, Yemane Hailu, Brahmam Pasumarthi, John Dogulas Palleti. Phytochemical Analysis and Evaluation of in vitro Antioxidant potential of Ethanolic Stem Bark Extract of Balanites aegyptiaca Del. Research Journal of Pharmacy and Technology, 2023; 16(9):4302-6. doi: 10.52711/0974-360X.2023.00704

Haftamu Tesfay Berihu, Tesfay Welderfael, Berihu Tekluu, V. K. Gopalakrishnan, M. Rama Rao, P. P. N. Vijay Kumar, U. Shameem, P. John Dogulas & K. Krishna Chaithanya. Anti-inflammatory and Cytotoxicity activities of Green Synthesized Silver Nanoparticles from Stem Bark of Terminalia brownii. BioNanoSci. 2021. https://doi.org/10.1007/s12668-021-00885-8

Ongoing Projects

1. Machine Learning in Bioinformatics:

  • Research Focus: Developing and applying machine learning models for genomic data analysis, such as variant calling, gene expression profiling, and evolutionary analysis.
  • Potential Topics: Predictive modeling for disease susceptibility, disease classification based on gene expression, and machine learning models for biomarker discovery.

2. Phytochemical Screening and Drug Discovery:

  • Research Focus: Investigating bioactive compounds from medicinal plants for their therapeutic potential.
  • Potential Topics: Screening and characterizing phytochemicals with antibacterial, antifungal, or antioxidant properties; using molecular docking to predict interactions between phytochemicals and disease-related proteins.

3. Environmental Bioinformatics and Ecosystem Health:

  • Research Focus: Applying bioinformatics to understand environmental health, pollution effects, and ecosystem resilience.
  • Potential Topics: Genomic analysis of microbes involved in bioremediation, the impact of pollution on microbial diversity, and predictive modeling for environmental health.

4. Genomic Data Analysis for Personalized Medicine:

  • Research Focus: Using genomics to understand individual variation in disease risk and drug response.
  • Potential Topics: Comparative genomics to identify personalized treatments for chronic diseases, genome-wide association studies for disease susceptibility, and pharmacogenomic approaches for tailored therapies.

5. Antimicrobial Resistance (AMR) Prediction and Mitigation:

  • Research Focus: Investigating antimicrobial resistance using computational and molecular approaches to help tackle AMR in pathogens.
  • Potential Topics: Prediction of resistance genes in bacterial genomes, computational models for AMR pathway analysis, and development of alternative antimicrobial compounds from natural sources.

6. Computational Modeling of Protein-Protein Interactions:

  • Research Focus: Studying protein interactions to understand cellular processes and identify drug targets.
  • Potential Topics: Structural modeling of protein complexes involved in diseases, computational docking studies to screen inhibitors, and machine learning to predict protein interaction networks.

7. Epigenetics and Disease Mechanisms:

  • Research Focus: Understanding how epigenetic modifications influence disease onset and progression.
  • Potential Topics: The role of DNA methylation in chronic kidney disease, histone modification patterns in cancer, and the impact of environmental factors on epigenetics in autoimmune disorders.

8. Computational Analysis of Non-Coding RNA:

  • Research Focus: Analyzing the roles of non-coding RNAs (e.g., miRNAs, lncRNAs) in gene regulation and disease.
  • Potential Topics: Functional characterization of miRNAs in kidney disease, bioinformatics approaches for non-coding RNA annotation, and network analysis of lncRNA interactions in cancer.

9. Air Quality Assessment and Health Impacts:

  • Research Focus: Assessing air pollution levels and their effects on public health, using computational models and data analysis.
  • Potential Topics: Monitoring air pollutants at highway junctions, assessing health risks from vehicle emissions, and developing predictive models for air quality and respiratory health.

10. Bioinformatics in Agriculture:

  • Research Focus: Applying bioinformatics tools to improve crop health, resilience, and productivity.
  • Potential Topics: Genomic analysis of crop plants for disease resistance, microbial diversity in soil health, and identifying gene markers for yield optimization.

11. Integrative Approaches in Chronic Kidney Disease (CKD):

  • Research Focus: Investigating the genetic, epigenetic, and environmental factors contributing to CKD.
  • Potential Topics: Genetic analysis of CKD risk variants, studying the role of mitochondrial DNA in kidney function, and identifying biomarkers for early detection.

12. Microbiome and Human Health:

  • Research Focus: Studying the human microbiome and its role in health and disease.
  • Potential Topics: Gut microbiome analysis in metabolic diseases, microbial dysbiosis and immune response, and the impact of dietary factors on microbiome composition.

13. Development of Bioinformatics Tools and Software:

  • Research Focus: Creating new computational tools and algorithms for analyzing biological data.
  • Potential Topics: Developing software for data visualization, pipeline automation for genomic analysis, and web-based platforms for multi-omics integration.

14. Bioinformatics in Mental Health and Neuroscience:

  • Research Focus: Exploring bioinformatics applications in understanding brain disorders.
  • Potential Topics: Identifying genetic risk factors for neurological diseases, machine learning models for psychiatric disorder prediction, and network analysis of brain gene expression.

15. Green Chemistry and Sustainable Biotechnology:

  • Research Focus: Applying bioinformatics and computational methods to green chemistry and biotechnology for sustainable solutions.
  • Potential Topics: Screening plant-based compounds for eco-friendly alternatives, computational approaches to enzyme optimization for biofuel production, and assessing environmental impacts of bioproducts.